Urotensin II, from fish to human.
Identifieur interne : 000744 ( France/Analysis ); précédent : 000743; suivant : 000745Urotensin II, from fish to human.
Auteurs : Hubert Vaudry [France] ; Jean-Claude Do Rego [France] ; Jean-Claude Le Mevel [France] ; David Chatenet [France] ; Hervé Tostivint [France] ; Alain Fournier [France] ; Marie-Christine Tonon [France] ; Georges Pelletier [Canada] ; J Michael Conlon [Émirats arabes unis] ; Jérôme Leprince [France]Source :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2010-07.
Abstract
The cyclic peptide urotensin II (UII) was originally isolated from the urophysis of teleost fish on the basis of its ability to contract intestinal smooth muscle. The UII peptide has subsequently been isolated from frog brain and, later on, the pre-proUII cDNA has been characterized in mammals, including humans. A UII paralog called urotensin II-related peptide (URP) has been identified in the rat brain. The UII and URP genes originate from the same ancestral gene as the somatostatin and cortistatin genes. In the central nervous system (CNS) of tetrapods, UII is expressed primarily in motoneurons of the brainstem and spinal cord. The biological actions of UII and URP are mediated through a G protein-coupled receptor, termed UT, that exhibits high sequence similarity with the somatostatin receptors. The UT gene is widely expressed in the CNS and in peripheral organs. Consistent with the broad distribution of UT, UII and URP exert a large array of behavioral effects and regulate endocrine, cardiovascular, renal, and immune functions.
Url:
DOI: 10.1111/j.1749-6632.2010.05514.x
Affiliations:
- Canada, France, Émirats arabes unis
- Haute-Normandie, Région Bretagne, Région Normandie
- Brest, Le Havre, Rouen
- Université de Bretagne Occidentale, Université de Rouen, Université du Havre, Université européenne de Bretagne
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000366
- to stream Hal, to step Curation: 000366
- to stream Hal, to step Checkpoint: 000423
- to stream Main, to step Merge: 000900
- to stream Main, to step Curation: 000893
- to stream Main, to step Exploration: 000893
- to stream France, to step Extraction: 000744
Links to Exploration step
Hal:pasteur-00819531Le document en format XML
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when="2010-07">2010-07</date><idno type="wicri:Area/Hal/Corpus">000366</idno><idno type="wicri:Area/Hal/Curation">000366</idno><idno type="wicri:Area/Hal/Checkpoint">000423</idno><idno type="wicri:doubleKey">0077-8923:2010:Vaudry H:urotensin:ii:from</idno><idno type="wicri:Area/Main/Merge">000900</idno><idno type="wicri:Area/Main/Curation">000893</idno><idno type="wicri:Area/Main/Exploration">000893</idno><idno type="wicri:Area/France/Extraction">000744</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Urotensin II, from fish to human.</title><author><name sortKey="Vaudry, Hubert" sort="Vaudry, Hubert" uniqKey="Vaudry H" first="Hubert" last="Vaudry">Hubert Vaudry</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1752" status="OLD"> <orgName>IFR multidisciplinaire sur les peptides</orgName> <orgName type="acronym">IMP</orgName> <desc> <address> <addrLine>Place Emile Blondel 76821 Mont Saint Aignan cedex</addrLine> <country 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type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle><tutelle active="#struct-301860" type="direct"><org type="institution" xml:id="struct-301860" status="VALID"> <orgName>CRLCC Henri Becquerel</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle name="IFR23" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle 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Rouen</orgName></affiliation></author><author><name sortKey="Do Rego, Jean Claude" sort="Do Rego, Jean Claude" uniqKey="Do Rego J" first="Jean-Claude" last="Do Rego">Jean-Claude Do Rego</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1697" status="VALID"><orgName>Unité de neuropsychopharmacologie expérimentale</orgName><orgName type="acronym">UNE</orgName><desc><address><addrLine>Faculté de Médecine et Pharmacie 22 boulevard Gambetta 76183 ROUEN CEDEX</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/univ/Recherche/equipes/UNE.html</ref></desc><listRelation><relation active="#struct-300318" type="direct"></relation><relation name="FRE2735" active="#struct-441569" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle><tutelle name="FRE2735" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno><idno type="IdRef">02636817X</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Le Mevel, Jean Claude" sort="Le Mevel, Jean Claude" uniqKey="Le Mevel J" 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xml:id="struct-222516" status="INCOMING"><orgName>Faculty of Medicine and Health Science</orgName><desc><address><addrLine>Al Ain</addrLine><country key="AE"></country></address></desc><listRelation><relation active="#struct-310195" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-310195" type="direct"><org type="institution" xml:id="struct-310195" status="INCOMING"><orgName>UAE University</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>Émirats arabes unis</country></affiliation></author><author><name sortKey="Leprince, Jerome" sort="Leprince, Jerome" uniqKey="Leprince J" first="Jérôme" last="Leprince">Jérôme Leprince</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1752" status="OLD"> <orgName>IFR multidisciplinaire sur les peptides</orgName> <orgName type="acronym">IMP</orgName> <desc> <address> <addrLine>Place Emile Blondel 76821 Mont Saint Aignan cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-rouen.fr/ifrmp23</ref> </desc> <listRelation> <relation active="#struct-300147" type="direct"></relation> <relation active="#struct-300317" type="direct"></relation> <relation active="#struct-300318" type="direct"></relation> <relation active="#struct-301860" type="direct"></relation> <relation name="IFR23" active="#struct-303623" type="direct"></relation> <relation name="IFR23" active="#struct-441569" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-300147" type="direct"><org type="institution" xml:id="struct-300147" status="VALID"><orgName>CHU Rouen</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-300317" type="direct"><org type="institution" xml:id="struct-300317" status="VALID"><orgName>Université du Havre</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle><tutelle active="#struct-301860" type="direct"><org type="institution" xml:id="struct-301860" status="VALID"> <orgName>CRLCC Henri Becquerel</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle name="IFR23" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="IFR23" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno><idno type="IdRef">02636817X</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Le Havre</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université du Havre</orgName><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author></analytic><idno type="DOI">10.1111/j.1749-6632.2010.05514.x</idno><series><title level="j">Annals of the New York Academy of Sciences</title><idno type="ISSN">0077-8923</idno><imprint><date type="datePub">2010-07</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="ro"><term>URP</term><term>UT</term><term>behavioral effects</term><term>cardiovascular system</term><term>evolution</term><term>urotensin II</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The cyclic peptide urotensin II (UII) was originally isolated from the urophysis of teleost fish on the basis of its ability to contract intestinal smooth muscle. The UII peptide has subsequently been isolated from frog brain and, later on, the pre-proUII cDNA has been characterized in mammals, including humans. A UII paralog called urotensin II-related peptide (URP) has been identified in the rat brain. The UII and URP genes originate from the same ancestral gene as the somatostatin and cortistatin genes. In the central nervous system (CNS) of tetrapods, UII is expressed primarily in motoneurons of the brainstem and spinal cord. The biological actions of UII and URP are mediated through a G protein-coupled receptor, termed UT, that exhibits high sequence similarity with the somatostatin receptors. The UT gene is widely expressed in the CNS and in peripheral organs. Consistent with the broad distribution of UT, UII and URP exert a large array of behavioral effects and regulate endocrine, cardiovascular, renal, and immune functions.</div></front></TEI><affiliations><list><country><li>Canada</li><li>France</li><li>Émirats arabes unis</li></country><region><li>Haute-Normandie</li><li>Région Bretagne</li><li>Région Normandie</li></region><settlement><li>Brest</li><li>Le Havre</li><li>Rouen</li></settlement><orgName><li>Université de Bretagne Occidentale</li><li>Université de Rouen</li><li>Université du Havre</li><li>Université européenne de Bretagne</li></orgName></list><tree><country name="France"><region name="Région Normandie"><name sortKey="Vaudry, Hubert" sort="Vaudry, Hubert" uniqKey="Vaudry H" first="Hubert" last="Vaudry">Hubert Vaudry</name></region><name sortKey="Chatenet, David" sort="Chatenet, David" uniqKey="Chatenet D" first="David" last="Chatenet">David Chatenet</name><name sortKey="Do Rego, Jean Claude" sort="Do Rego, Jean Claude" uniqKey="Do Rego J" first="Jean-Claude" last="Do Rego">Jean-Claude Do Rego</name><name sortKey="Fournier, Alain" sort="Fournier, Alain" uniqKey="Fournier A" first="Alain" last="Fournier">Alain Fournier</name><name sortKey="Le Mevel, Jean Claude" sort="Le Mevel, Jean Claude" uniqKey="Le Mevel J" first="Jean-Claude" last="Le Mevel">Jean-Claude Le Mevel</name><name sortKey="Leprince, Jerome" sort="Leprince, Jerome" uniqKey="Leprince J" first="Jérôme" last="Leprince">Jérôme Leprince</name><name sortKey="Tonon, Marie Christine" sort="Tonon, Marie Christine" uniqKey="Tonon M" first="Marie-Christine" last="Tonon">Marie-Christine Tonon</name><name sortKey="Tostivint, Herve" sort="Tostivint, Herve" uniqKey="Tostivint H" first="Hervé" last="Tostivint">Hervé Tostivint</name></country><country name="Canada"><noRegion><name sortKey="Pelletier, Georges" sort="Pelletier, Georges" uniqKey="Pelletier G" first="Georges" last="Pelletier">Georges Pelletier</name></noRegion></country><country name="Émirats arabes unis"><noRegion><name sortKey="Conlon, J Michael" sort="Conlon, J Michael" uniqKey="Conlon J" first="J Michael" last="Conlon">J Michael Conlon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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